Formulation Senior Research Scientist Job at Vertex Pharmaceuticals
Job Description
The Formulation Senior Research Scientist will work with other scientists dedicated to advancing drug candidates from exploratory development through commercial line extension in a Quality by Design (QbD) environment using lab based and computational tools to design and select dosage forms and manufacturing process. This role designs and executes elaborate experiments for pharmaceutical sciences projects and demonstrates resourcefulness in running multiple activities concurrently, all related to achievement of goals/objectives.
Key Duties and Responsibilities:
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Develop dosage forms for clinical and commercial use
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Develop stable and bioavailable formulations for different stages of development (e.g. solution/suspension based formulations, amorphous pharmaceutical systems into solid oral dosage forms, parenterals, etc.)
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Designs and performs technically challenging experiments in compliance with applicable regulations and SOPs
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Interprets moderately complicated, multidimensional data and makes recommendations on new processes and development directions
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Performs relatively advanced experimental troubleshooting and methods development
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"Multi-tasks" to effectively manage efforts on multiple activities and/or projects
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Scours relevant scientific literature within field and surveys broadly beyond own discipline/field
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May innovate technical methodologies to improve outcomes and achieve results
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Contributes to patent and publication preparation
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"Imports" new principles/concepts from other fields to develop useful new experimental approaches
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May be the practical manager of CRO contracts or external collaborative development
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May supervise other Pharmaceutical Operations staff and may be responsible for quality, timeliness and accuracy of work done of others
Knowledge and Skills:
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Sound knowledge of pharmaceutical and engineering principles in the solid dosage form development
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Hands on experience with formulation techniques, processing equipment, and unit operations at both the laboratory and clinical manufacturing scales
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Strong math skills
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Strong technical writing, verbal and written communication skills
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Successful and efficient multitasking and working on a few projects concurrently
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Detail-oriented
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Strong background in physical chemistry and good understanding of material properties
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Experience working with small molecule new chemical entities (NCEs) and formulation development activities
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Experience with a range of dosage forms
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Proven experience managing the scale-up and manufacturing of solid oral dosage forms
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Proven ability to apply the principles of the basic sciences, such as physical and organic chemistry, thermodynamics, and materials science and formulation development, using a rational, scientific approach
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A history of success working in environments defined by innovation and initiative
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Ability to work effectively and comfortably in a multi-disciplinary team under defined timelines
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Excellent leadership, teamwork and organizational skills
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Solid verbal and written communication skills
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GLP, GMP and GxP experience
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Strong data analysis skills
Education and Experience:
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PhD in pharmaceutical sciences, chemistry, chemical engineering, materials sciences or related field and 2+ years of experience in life sciences, engineering or academia, or
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Master's Degree in pharmaceutical sciences, chemistry, chemical engineering, materials sciences or related field and 5+ years of experience in life sciences, engineering or academia, or
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Bachelor's Degree in pharmaceutical sciences, chemistry, chemical engineering, materials sciences or related field and 8+ years of experience in life sciences, engineering or academia
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Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Please note that Vertex requires COVID-19 vaccination for all employees working in the U.S. as a condition of employment at Vertex, subject to medical, religious or other accommodations or exemptions required by law. We believe this requirement is vital to keeping everyone at Vertex and in our communities safe. This requirement applies to both existing and new employees who may at any time work on-site at a Vertex facility or visit another location on behalf of Vertex (e.g., conferences, customer visits, etc.), including all remote employees. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.
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